Take alendronate with a full glass (6 to 8 ounces) of plain water on an empty stomach. It should be taken in the morning at least 30 minutes before any food, beverage, or other medicines. Food and beverages, such as mineral water, coffee, tea, or juice, will decrease the amount of alendronate absorbed by the body. Waiting longer than 30 minutes will allow more of the drug to be absorbed. Medicines such as antacids or calcium or vitamin supplements will also decrease the absorption of alendronate. Do not lie down for 30 minutes after taking alendronate. This will help alendronate reach your stomach faster. It will also help prevent irritation to your esophagus. Your doctor may recommend that you eat a balanced diet with an adequate amount of calcium and vitamin D (found in milk or other dairy products. However, do not take any food, beverages, or calcium or vitamin supplements within 30 minutes of taking alendronate. To do so may keep this medicine from working properly. Waiting longer than 30 minutes will allow more of the drug to be absorbed.

Alendronate is in the group of medicines called bisphosphonates (bis FOS fo nayts). It alters the cycle of bone formation and breakdown in the body. Alendronate slows bone loss while increasing bone mass, which may prevent bone fractures.

Check with your doctor as soon as possible if any of the following side effects occur. More common: Abdominal pain. Less common: Difficulty in swallowing; heartburn; irritation or pain of the esophagus; muscle pain. Rare: Skin rash.

Make certain your health care professional knows if you are on any special diet, such as a low-sodium or low-sugar diet. Your doctor may recommend that you eat a balanced diet with an adequate amount of calcium and vitamin D (found in milk or other dairy products.