Recommended 1st line treatment for chlamydia
Used for
Treats chlamydia by killing the bacteria causing the infection.
How to use it*
Take 100 mg twice daily for 7 days with food and a full glass of water. Avoid lying down for 30 minutes after taking.
How long to work
Relief usually begins in 2 to 3 days. Finish the full course.
Common side effects*
Nausea, stomach upset, diarrhea and sensitivity to sunlight.
Who should not take it*
Avoid if pregnant, breastfeeding, or have liver or kidney issues.
Interactions*
Avoid antacids, iron, dairy, and alcohol. May interact with blood thinners.
Generic/branded
Generic: Doxycycline.
Brand: Vibramycin.
* Always consult the patient leaflet for comprehensive information.
Doxycycline is a broad-spectrum antibiotic that treats bacterial infections and STIs such as chlamydia, syphilis, and gonorrhea.
Doxycycline is approved by the FDA and is sold in tablet, capsule, and liquid form. It is available as a generic drug and under various brand names.
At SpeedyHealth, our doctors are able to prescribe 100mg of Doxycycline capsules after you complete an online consultation.
In the US, chlamydia trachomatis (CT) is the most common sexually transmitted infection, with a staggering 1.6 million cases reported back in 2021. If left untreated, it can affect reproductive health, cause ectopic pregnancy (where the fetus is outside of the womb), and infertility.
Doxycycline treats STIs such as chlamydia by stopping the STI-causing bacteria from growing and multiplying. The medicine binds to the bacteria’s protein-producing unit, the 30S ribosomal subunit, and prevents it from producing protein essential for survival and stopping its growth.
As Doxycycline targets bacterial infections, there are multiple benefits of taking it to treat illnesses and diseases, for example:
Doxycycline is highly effective for treating chlamydia. A 2021 study explored whether Doxycycline helps treat rectal chlamydia in men having sex with men.
The study involved 177 participants who were diagnosed with rectal chlamydia. All participants were men who had sex with men. Seventy participants were given Doxycycline for 7 days, and 65 participants were given a single dose of Azithromycin for a day.
At the 4-week follow-up, the results showcased just how effective Doxycycline is.
Doxycycline
Azithromycin
Another study involved 416 women. Out of this, 319 women suffered from both rectal and vaginal chlamydia, 22 women suffered from only rectal chlamydia, and 75 women had only vaginal chlamydia. The women were either given 100 mg Doxycycline twice a day for 7 days or a 1 gm single dose of Azithromycin.
At the 4-week follow-up visit, the results showed that, once again, Doxycycline is a much more reliable treatment choice than Azithromycin.
Women's Treatment Study
416 Total Participants
Doxycycline
Azithromycin
Doxycycline
Azithromycin
At SpeedyHealth, Doxycycline is available in 100 mg capsules. To treat chlamydia, the recommended Doxycycline dosage is one 100 mg capsule orally twice a day for 7 days.
Before taking Doxycycline, make sure you:
If you miss a dose of Doxycycline, take it as soon as you remember it. Take your next dose at the scheduled time. Do not take a double dose to compensate for the missed dose.
Once you start taking Doxycycline for STIs, you will usually begin to feel better within 7 to 10 days. It is also important to complete the full course of Doxycycline as prescribed, even if your symptoms start to get better. Stopping the treatment early can cause the infection to return.
If your infection worsens or you develop a new infection, seek medical attention.
Depending on your condition, you must take Doxycycline for as long as the doctor has prescribed it. However, the usual treatment course for chlamydia with Doxycycline lasts for 7 days.
Do not stop taking Doxycycline in the middle of treatment, as this can cause unwanted side effects, or the infection may return. It may also make the bacteria more resistant to other antibiotics.
If you are concerned about the treatment duration or any of the medicine’s side effects, discuss this with your healthcare provider.
Like other medicines, Doxycycline may cause side effects.
If you experience any serious or rare side effects, or if your side effects get worse or do not resolve, seek medical attention. To know more about Doxycycline side effects, refer to the Patient Information Leaflet.
While Doxycycline is generally a safe medicine, it might not be suitable for everyone.
You can take this medicine if you are an adult who has had unprotected sex and wants to reduce the risk of getting STIs such as chlamydia.
Alternatively, you can take Doxycycline if you are an adult suffering from STIs and are looking for an effective treatment.
Do not take this medicine if you are allergic to Doxycycline or any other ingredients present in this medicine.
You should also speak to your doctor before taking Doxycycline if any of the following apply to you:
While Doxycycline can be useful in treating several bacterial infections, there are a few things you can do to ensure it remains effective:
Practice safe sex
Use protection such as a condom or a dental dam while having sex with your partner to avoid getting infected.
Communicate with your sexual partner
Inform your sexual partner if you have tested positive for chlamydia so that your partner can do the same for their safety as well.
Do not share sex toys
Ensure that you are not sharing your sex toys with your partner and vice-versa. Clean them with gentle soap and water every time you use them to prevent chlamydia from getting worse.
| Category | Safety | Advice |
|---|---|---|
| Alcohol | Avoid | Avoid drinking alcohol as it may decrease the effectiveness of Doxycycline. |
| Pregnancy | Avoid | Doxycycline is contraindicated in pregnancy. It is best to avoid taking this medicine if you are pregnant or planning to become pregnant. |
| Breastfeeding | Avoid | Doxycycline affects breastfeeding mothers. It is best to avoid taking this medicine if you are nursing or breastfeeding. |
| Driving | Safe | This medicine doesn’t affect your ability to drive. |
| Sun exposure | Avoid | This medicine can make your skin sensitive to sunlight. Avoid sun exposure or wear protective clothing to protect your skin from sunlight. |
Store Doxycycline at or below 77℉. Keep it out of reach of children and pets and away from direct heat and sunlight. Store it in a dry place, and do not use it past the expiry date.
Do not throw away unused or expired capsules in your garbage bin or flush them down your toilet. Instead, take them to your local pharmacy and ask them to dispose of them.
No, you cannot buy Doxycycline over the counter. This antibiotic is only available with a doctor’s prescription.
If you need a prescription, you can complete our short consultation form. If one of our doctors approves it, you will receive your prescription electronically.
Yes, you can buy Doxycycline online from SpeedyHealth. All you need to do is:
Your privacy is our top priority. SpeedyHealth uses secure, encrypted transactions and complies with USA medical standards to maintain confidentiality.
Doxycycline is generally preferred for treating chlamydia as it is highly effective. If Doxycycline is not suitable for you, Azithromycin is a good alternative.
Doxycycline
Effectiveness:
99% cure rate
CDC recommended first-line treatment
CDC status:
First-line treatment
Primary recommended option
Dosing schedule:
Two doses per day
100mg twice daily for 7 days
PRICE :- $64.99
Azithromycin
Effectiveness:
83-95% cure rate
For rectal infections
CDC status:
Alternative treatment
Recommended alternative
Dosing Schedule:
Single 1g dose
Complete treatment in one dose
PRICE :- $64.99
Both Doxycycline and Azithromycin are effective in treating STIs. However, Doxycycline is slightly more effective, has milder side effects, and is less expensive than Azithromycin.
Doctors also do not recommend Azithromycin any longer for bacterial infections due to its bacterial resistance, which makes Doxycycline the better option.
Here’s why you should choose SpeedyHealth to manage your medicines easily:
Medically reviewed by Dr. Adrian Rawlinson
Written by our editorial team | Last reviewed January 28, 2026
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