Sleep deep, wake refreshed

Say goodbye to disrupted sleep and long nights with Doxepin. It helps you stay asleep and boosts your total rest by up to 30 without causing daytime drowsiness.

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  • Prescribed by board-certified physicians
  • No insurance needed
FDA Approved Drugs

Doxepin

3mg (starting dose)
3mg (starting dose)
6mg
30 pills Suitable for 30 days
$99.99
$99.99 Incl. Rx and shipping
Why choose Doxepin
  • Effective – Improves total sleep time by 30 minutes and increases sleep efficiency by 15%.
  • Gentle on cognition – Low doses rarely cause next-day drowsiness or memory issues.
  • Sleep maintenance – Specifically approved to reduce nighttime awakenings.
  • Dual benefit – May ease mild anxiety or mood symptoms alongside insomnia.
Good to know*
  • Common side effects include mild headache, dry mouth and occasional dizziness.
  • Do not take within 3 hours of a meal to reduce risk of drowsiness.
  • Avoid alcohol to reduce risk of drowsiness.
Delivery & discretion
  • Free shipping on all orders
  • Delivery in 2-3 working days
  • Need it quick: priority shipping option available in checkout
  • Comes in plain packaging
Our service
  • No insurance needed
  • No in-person doctor visit needed with our quick online consultation
  • No prescription needed
  • Reviewed by US-licensed physicians
  • Dispensed from US -licensed pharmacy
  • FDA-approved medication

How to use

Doxepin

Start low

Start low

Begin with one 3 mg capsule nightly, 30 minutes before bedtime.

Swallow whole with water or milk. Do not crush or chew.

Wait

Prevent next-day drowsiness

To minimize the risk of next-day effects, avoid taking Doxepin within 3 hours of eating.

Limit alcohol consumption, and if you choose to drink, do so a few hours before taking your Doxepin dose.

Symptom-free

Maintain schedule

Take at the same time each night; do not take a double dose.

After one week, if symptoms do not improve, talk to our doctor about increasing to 6 mg.

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Key facts

Doxepin

key facts banner
  • Used for

    Treats insomnia - helps falling asleep and reduces frequent sleep interruptions.

  • How to use it*

    Take one tablet once daily, 30 minutes before bedtime.

  • How long to work

    Noticeable sleep benefits often starting as early as the first night.

  • Common side effects*

    Headache, dry mouth, occasional dizziness.

  • Who should not take it*

    Patients on MAOIs, or with untreated narrow angle glaucoma, severe urinary retention, or severe liver disease.

  • Interactions*

    Alcohol, food and other CNS depressants increase drowsiness risk.

  • Generic/branded

    Generic: doxepin.
    Brand: Silenor.

* Always consult the patient leaflet for comprehensive information.

About Doxepin

What is Doxepin and how does it work?

Doxepin is a prescription medication used to treat insomnia. It belongs to a class of drugs called tricyclic antidepressants.

Doxepin treats insomnia by blocking histamine receptors in the brain. This helps reduce wakefulness and promotes longer, more restful sleep.

How to use Doxepin

Who can use Doxepin?

Doxepin is suitable for adults with insomnia. It's safe for most people to take, but there are some exceptions.

You should not take this medicine if you are allergic to the active ingredient, Doxepin hydrochloride, to any of the other ingredients in this medicine, or to other dibenzoxepines.

You should also avoid Doxepin if you are breastfeeding, have untreated narrow angle glaucoma, or severe urinary retention.

Consult your doctor before taking Doxepin if you have any of the following medical conditons:

  • Mental illness
  • Heart disease
  • Liver or kidney problems
  • Diabetes

Tell your doctor if you take any other medicines, natural health products, or supplements.

Doxepin may affect how some medicines work and vice versa. Especially tell your doctor if you take or have recently taken:

  • Monoamine Oxidase Inhibitors (MAOIs)
  • Medicines for depression (e.g. fluoxetine)
  • Medicines for reflux and stomach ulcers (e.g. cimetidine)
  • Medicines for diabetes (e.g. tolazamide)
  • Sedating antihistamines
  • Anti-anxiety medicines (e.g. diazepam)
  • Medicines containing atropine
  • Medicines for schizophrenia, or bipolar disorder (e.g. risperidone)
  • Medicines for an abnormal heartbeat
  • Certain epilepsy medicines
  • Medicines containing adrenaline or noradrenaline
  • Stimulant medicines containing amphetamine (e.g. dexamphetamine)
  • Guanethidine
  • Opioids e.g. (buprenorphine)

Avoid alcohol when taking Doxepin as this may increase its sedative effects.

For a complete list of precautions and medicine interactions, consult the patient information leaflet.

What dose do I start with?

If you have never taken this medication before, the recommended starting dose is 3mg.

Can I take Doxepin with food?

It’s best not to take this medicine with food. A high-fat meal can delay how fast the medicine works and increase the risk of next-day drowsiness.

How long does it take to work?

Doxepin reaches peak levels in the body around 3.5 hours after taking a dose. Most people notice improved sleep on the first night however, for some people, it may take a few days to see full effects.

Safety & side effects

What are the possible side effects?

Common side effects:

  • Drowsiness
  • Dizziness
  • Lightheadedness
  • Bad dreams
  • Dry mouth
  • Blurred vision
  • Difficulty urinating
  • Feeling sick, or vomiting
  • Indigestion
  • Constipation, or diarrhea
  • Changes in taste and appetite
  • Mouth ulcers
  • Numbness

Serious side effects:

You should stop taking Doxepin and seek immediate medical attention if you experience any of the following side effects:

  • Abnormal thinking and behavioral changes
  • Symptoms of allergy such as a skin rash, increased sweating, swelling of the face, tongue, lips, or throat, and difficulty breathing
  • Suicidal thoughts or thoughts of self-harm
  • Anxiety, nervousness, or aggressive behaviour
  • Fast or irregular heart beat
  • Chest pain
  • Changes in vision (e.g. vision worsening, blurred vision or seeing haloes around lights)

Buying Doxepin

Can I buy Doxepin online?

Yes, you can buy Doxepin tablets online at SpeedyHealth after completing our free online consultation.

How do I get a prescription for Doxepin?

You must complete an online consultation as Doxepin is a prescription-only medication. This process is quick and easy and allows our doctors to ensure this medicine is safe for you to take.

Medically reviewed by Dr. Adrian Rawlinson

Written by our editorial team | Last reviewed January 08, 2026

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